Tuesday, November 26, 2013

roundup jacking up human guts?

mdpi | Abstract: Glyphosate, the active ingredient in Roundup®, is the most popular herbicide used worldwide. The industry asserts it is minimally toxic to humans, but here we argue otherwise. Residues are found in the main foods of the Western diet, comprised primarily of sugar, corn, soy and wheat. Glyphosate's inhibition of cytochrome P450 (CYP) enzymes is an overlooked component of its toxicity to mammals. CYP enzymes play crucial roles in biology, one of which is to detoxify xenobiotics. Thus, glyphosate enhances the damaging effects of other food borne chemical residues and environmental toxins. Negative impact on the body is insidious and manifests slowly over time as inflammation damages cellular systems throughout the body. Here, we show how interference with CYP enzymes acts synergistically with disruption of the biosynthesis of aromatic amino acids by gut bacteria, as well as impairment in serum sulfate transport. Consequences are most of the diseases and conditions associated with a Western diet, which include gastrointestinal disorders, obesity, diabetes, heart disease, depression, autism, infertility, cancer and Alzheimer’s disease. We explain the documented effects of glyphosate and its ability to induce disease, and we show that glyphosate is the “textbook example” of exogenous semiotic entropy: the disruption of homeostasis by environmental toxins.

Keywords: glyphosate; cytochrome P450; eNOS; obesity; cardiovascular disease; cancer; colitis; shikimate pathway; gut microbiome; tryptophan; tyrosine; phenylalanine; methionine; serotonin; Alzheimer’s disease; Parkinson’s disease; autism; depression

Wednesday, November 13, 2013

the mcrib: enjoy your symptom


theatlantic | Each year, the McRib makes a brief visit to Earth. Its arrival elicits reactions ranging from horror to awe. And for good reason: this would-be rib sandwich is really a restructured pork patty pressed into the rough shape of a slab of ribs, its slathering of barbecue sauce acting as camouflage as much as coating.

“Pork” is a generous term, since the McRib has traditionally been fashioned from otherwise unmarketable pig parts like tripe, heart, and stomach, material that is not only cheap but also easier to mold and bind into a coherent, predetermined shape. McDonald’s accurately lists the patty’s primary ingredient as “boneless pork,” although even that’s a fairly strong euphemism. Presumably few of the restaurant’s patrons would line up for a Pressed McTripe.

Despite its abhorrence, the McRib bears remarkable similarity to another, more widely accepted McDonald’s product, the Chicken McNugget. In fact, the McRib was first introduced in 1982, shortly after the company had designed the McNugget. Chicken McNuggets are fashioned by the same method as is the McRib, namely by grinding factory-farmed chicken meat into a mash and then reconstituting them into a preservative-stabilized solid, aka a “nugget.” And both products are bound and preserved by a petrochemical preservative called tertiary butylhydroquinone, or TBHQ. According to the Consumer’s Dictionary of Food Additives, one gram of TBHQ can cause “nausea, vomiting, ringing in the ears, delirium, a sense of suffocation, and collapse.” In a 2003 lawsuit accusing McDonald’s of consumer deception, federal district court judge Robert W. Sweet called Chicken McNuggets a “McFrankenstein creation.”

But despite rejoinders like that of Judge Sweet, the Chicken McNugget flies under the radar, hiding its falseness, while the McRib flaunts it. In part, this is because the concept of a Chicken McNugget corresponds with a possible natural configuration of ordinary poultry, whose meat could be cut into chunks, battered, and fried. By contrast, there is no world in which pork spare ribs could be eaten straight through, even after having been slow cooked such that some of the cartilage breaks down. It’s a partial explanation for the horror and the delight wrought by McRib, but not a sufficient one.