mdpi | Abstract: Glyphosate, the active ingredient in Roundup®,
is the most popular herbicide used worldwide. The industry asserts it
is minimally toxic to humans, but here we argue otherwise. Residues are
found in the main foods of the Western diet, comprised primarily of
sugar, corn, soy and wheat. Glyphosate's inhibition of cytochrome P450
(CYP) enzymes is an overlooked component of its toxicity to mammals. CYP
enzymes play crucial roles in biology, one of which is to detoxify
xenobiotics. Thus, glyphosate enhances the damaging effects of other
food borne chemical residues and environmental toxins. Negative impact
on the body is insidious and manifests slowly over time as inflammation
damages cellular systems throughout the body. Here, we show how
interference with CYP enzymes acts synergistically with disruption of
the biosynthesis of aromatic amino acids by gut bacteria, as well as
impairment in serum sulfate transport. Consequences are most of the
diseases and conditions associated with a Western diet, which include
gastrointestinal disorders, obesity, diabetes, heart disease,
depression, autism, infertility, cancer and Alzheimer’s disease. We
explain the documented effects of glyphosate and its ability to induce
disease, and we show that glyphosate is the “textbook example” of
exogenous semiotic entropy: the disruption of homeostasis by
environmental toxins.
Keywords: glyphosate;
cytochrome P450; eNOS; obesity; cardiovascular disease; cancer;
colitis; shikimate pathway; gut microbiome; tryptophan; tyrosine;
phenylalanine; methionine; serotonin; Alzheimer’s disease; Parkinson’s
disease; autism; depression
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